Publications

Selected publications

Pal P, Balaban AE, Diamond MS, Sinnis P, Klein RS, Goldberg DE. Plasmodium falciparum histidine-rich protein II causes vascular leakage and exacerbates experimental cerebral malaria in mice. PLoS One. 2017 May 5; 12(5):e0177142. doi: 10.1371/journal.pone.0177142. PMID: 28475625.

Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg
DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nat
Commun. 2017 Jan 20;8:14240. doi: 10.1038/ncomms14240. PMID: 28106035.

Spillman NJ, Beck JR, Ganesan SM, Niles JC, Goldberg DE. The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol. Cell Microbiol. 2017 Jan 9. doi: 10.1111/cmi.12719. PMID: 28067475.

Spillman NJ, Dalmia VK, Goldberg DE. Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection. MBio. 2016 Oct 18;7(5). pii: e01538-16. doi: 10.1128/mBio.01538-16. PubMed PMID: 27795395

Sigala PA, Morante K, Tsumoto K, Caaveiro JM, Goldberg DE. In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis. Biochemistry. 2016 Aug 15. PMID: 27490825.

Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE. Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis. MBio. 2016 Jun 7;7(3). pii: e00617-16. doi: 10.1128/mBio.00617-16. PMID: 27273825.

Goldberg DE. Plasmepsin V shows its carnivorous side. Nat Struct Mol Biol. 2015 Sep;22(9):647-8. doi: 10.1038/nsmb.3077. PMID: 26333709.

Sigala PA, Crowley JR, Henderson JP, Goldberg DE. Deconvoluting heme biosynthesis to target blood-stage malaria parasites. Elife. 2015 Jul 14;4. doi: 10.7554/eLife.09143. PubMed PMID: 26173178.

Spillman NJ, Beck JR, Goldberg DE. Protein export into malaria parasite-infected erythrocytes: mechanisms and functional consequences. Annu Rev Biochem. 2015;84:813-41. doi: 10.1146/annurev-biochem-060614-034157. Epub 2015 Jan 26. PubMed PMID: 25621510.

Mallari JP, Oksman A, Vaupel B, Goldberg DE. Kinase-associated endopeptidase 1 (Kae1) participates in an atypical ribosome-associated complex in the apicoplast of Plasmodium falciparum. J Biol Chem. 2014 Oct 24;289(43):30025-39. doi: 10.1074/jbc.M114.586735. Epub 2014 Sep 9. PubMed PMID: 25204654.

Beck JR, Muralidharan V, Oksman A, Goldberg DE. PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes. Nature. 2014 Jul 31;511(7511):592-5. doi: 10.1038/nature13574. Epub 2014 Jul 16. PubMed PMID: 25043010.

Sigala PA, Goldberg DE. The peculiarities and paradoxes of Plasmodium heme metabolism. Annu Rev Microbiol. 2014;68:259-78. doi: 10.1146/annurev-micro-091313-103537. Epub 2014 Jun 16. Review. PubMed PMID: 25002093.

Muralidharan V, Goldberg DE. Asparagine repeats in Plasmodium falciparum proteins: good for nothing? PLoS Pathog. 2013;9(8):e1003488. doi: 10.1371/journal.ppat.1003488. Epub 2013 Aug 22. Review. PubMed PMID: 23990777.

Goldberg DE. Complex nature of malaria parasite hemoglobin degradation [corrected]. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5283-4. doi: 10.1073/pnas.1303299110. Epub 2013 Mar 19. Erratum in: Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):7097. PubMed PMID: 23513214.

Goldberg DE. Plasmodium protein export at higher PEXEL resolution. Cell Host Microbe. 2012 Nov 15;12(5):609-10. doi: 10.1016/j.chom.2012.11.001. PubMed PMID: 23159050.

Muralidharan V, Oksman A, Pal P, Lindquist S, Goldberg DE. Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. Nat Commun. 2012;3:1310. doi: 10.1038/ncomms2306. PubMed PMID: 23250440.

Babbitt SE, Altenhofen L, Cobbold SA, Istvan ES, Fennell C, Doerig C, Llinás M, Goldberg DE. Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3278-87. doi: 10.1073/pnas.1209823109. Epub 2012 Oct 29. PubMed PMID: 23112171.

Sigala PA, Crowley JR, Hsieh S, Henderson JP, Goldberg DE. Direct tests of enzymatic heme degradation by the malaria parasite Plasmodium falciparum. J Biol Chem. 2012 Nov 2;287(45):37793-807. doi: 10.1074/jbc.M112.414078. Epub 2012 Sep 19. PubMed PMID: 22992734.

Meyers MJ, Goldberg DE. Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts. Curr Top Med Chem. 2012;12(5):445-55. Review. PubMed PMID: 22242846.

Ndonwi M, Burlingame OO, Miller AS, Tollefsen DM, Broze GJ Jr, Goldberg DE. Inhibition of antithrombin by Plasmodium falciparum histidine-rich protein II. Blood. 2011 Jun 9;117(23):6347-54. doi: 10.1182/blood-2010-12-326876. Epub 2011 Apr 21. PubMed PMID: 21511958.

Muralidharan V, Oksman A, Iwamoto M, Wandless TJ, Goldberg DE. Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4411-6. doi: 10.1073/pnas.1018449108. Epub 2011 Feb 28. PubMed PMID: 21368162.

Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1627-32. doi: 10.1073/pnas.1011560108. Epub 2011 Jan 4. PubMed PMID: 21205898.

Russo I, Babbitt S, Muralidharan V, Butler T, Oksman A, Goldberg DE. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature. 2010 Feb 4;463(7281):632-6. doi: 10.1038/nature08726. PubMed PMID: 20130644.

Russo I, Oksman A, Goldberg DE. Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Mol Microbiol. 2009 Apr;72(1):229-45. doi: 10.1111/j.1365-2958.2009.06639.x. Epub 2009 Feb 23. PubMed PMID: 19239622.

Russo I, Oksman A, Vaupel B, Goldberg DE. A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1554-9. doi: 10.1073/pnas.0806926106. Epub 2009 Jan 22. PubMed PMID: 19164769.

Drew ME, Banerjee R, Uffman EW, Gilbertson S, Rosenthal PJ, Goldberg DE. Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 9;283(19):12870-6. doi: 10.1074/jbc.M708949200. Epub 2008 Feb 28. PubMed PMID: 18308731.

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